L. J. Blaine

Epistasis and physico-chemical constraints contribute to spatial clustering of amino acid substitutions in protein evolution.

The paper examines spatial clustering of amino acid substitutions across species and finds that epistasis and convergent evolution, rather than thermodynamic constraints, drive this pattern.

Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error

This study identifies a mutational cascade triggered by chromosome bridge formation that leads to chromothripsis and contributes to cancer genome complexity and sub-clonal heterogeneity.