A. Malnasi-Csizmadia

This study reveals that riluzole inhibits sodium channels through non-blocking modulation rather than block, using conformation-selective photolabeling to identify binding sites and mechanisms.

This study shows that E. coli SSB forms liquid-liquid phase-separated condensates through interactions with ssDNA and other proteins, enabling rapid mobilization for DNA repair.

This study shows that non-blocking modulation of sodium channels is possible using a covalently attached photoreactive riluzole analog, suggesting new avenues for drug development.