Author

P. Lukacs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 4 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Mike· 4 shared K. Pesti· 3 shared K. Zboray· 3 shared M. C. Foldi· 3 shared A. Malnasi-Csizmadia· 2 shared A. V. Toth· 2 shared B. Biri-Kovacs· 1 shared E. Casanova· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersPharmacology & Toxicology

A. Mike

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4 papers

Recent·Most cited

Compound-specific, concentration-independent biophysical properties of sodium channel inhibitor mechanism of action

K. Pesti, M. C. Foldi, K. Zboray, A. V. Toth, P. Lukacs, A. Mike

This study quantifies compound-specific biophysical properties of sodium channel inhibitors, independent of concentration, to reveal their mechanism of action.

bioRxiv · Jul 5, 2021 · PreprintPharmacology & Toxicology

An advanced automated patch clamp protocol design to investigate drug - ion channel binding dynamics.

P. Lukacs, K. Pesti, M. C. Foldi, K. Zboray, A. V. Toth, G. Papp, A. Mike

This study introduces an automated patch-clamp protocol to assess drug-sodium channel binding dynamics, revealing complex on- and off-kinetics across multiple time scales.

bioRxiv · Jul 5, 2021Pharmacology & Toxicology

Mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling

M. C. Földi, K. Pesti, K. Zboray, T. Hegedus, A. Malnasi-Csizmadia, P. Lukacs, A. Mike

This study reveals that riluzole inhibits sodium channels through non-blocking modulation rather than block, using conformation-selective photolabeling to identify binding sites and mechanisms.

bioRxiv · May 5, 2020Pharmacology & Toxicology

Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog

P. Lukacs, M. C. Foldi, L. Valanszki, E. Casanova, B. Biri-Kovacs, L. Nyitray, A. Malnasi-Csizmadia, A. Mike

This study shows that non-blocking modulation of sodium channels is possible using a covalently attached photoreactive riluzole analog, suggesting new avenues for drug development.

bioRxiv · Dec 4, 2017Pharmacology & Toxicology