Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity
B. M. Fernandez-Ciruelos, M. Albanese, A. Adhav, V. Solomin, A. Ritchie-Martinez, F. Taverne, N. Velikova, A. Jirgensons, A. Marina, P. W. Finn, J. M. Wells
This study repurposes Hsp90 inhibitors as antimicrobials targeting bacterial two-component systems, finding that DPP analogues disrupt bacterial membranes and show antimicrobial activity against Gram-positive bacteria.
Microbiology Spectrum · Aug 6, 2024Peer-reviewedMicrobiology