J. M. Wells

Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity

This study repurposes Hsp90 inhibitors as antimicrobials targeting bacterial two-component systems, finding that DPP analogues disrupt bacterial membranes and show antimicrobial activity against Gram-positive bacteria.

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs

This study traces the emergence and spread of Streptococcus suis pathogens in pigs, linking their evolution to changes in farming practices and identifying genomic factors associated with pathogenicity.

Cross-talk between QseBC and PmrAB two-component systems is crucial for regulation of motility and colistin resistance in Enteropathogenic Escherichia coli

This study investigates the role of QseBC in regulating motility and colistin resistance in atypical EPEC and its cross-talk with PmrAB and KdpDE TCS.

Transcriptomics in serum and culture medium reveal shared and differential gene regulation in pathogenic and commensal Streptococcus suis

This study compares transcriptomes of pathogenic and commensal Streptococcus suis strains in different media, finding conserved gene regulation in serum but divergent pathway expression.

Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients

This study shows that enteroendocrine cells regulate crypt metabolism and intestinal stem cell function by transmitting nutrient status to the stem cell niche.

Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis

This study uses spatial transcriptomics to analyze SARS-CoV-2 infection in coronary endothelial and myocardial tissues from COVID-19 patients, finding unique pro-inflammatory profiles in capillaries but not larger vessels.

Streptococcus suis infection on European farms is associated with an altered tonsil microbiome and resistome

The paper investigates the association between Streptococcus suis infection in piglets and changes in their tonsil microbiome and resistome, finding altered microbial composition and increased antimicrobial resistance genes.

High fat diet initiates rapid adaptation of the intestine

This study shows that a high fat diet rapidly alters intestinal epithelial cell function and composition within days, including stress responses and shifts in metabolic and absorptive capabilities.

Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport

This study identifies peptide YY as a regulator of ion-coupled nutrient absorption in the small intestine, showing its therapeutic potential for malabsorption.

Complement active human and porcine serum induces natural competence for genetic transformation in the emerging zoonotic pathogen Streptococcus suis

The paper shows that active human and porcine serum induces natural competence in Streptococcus suis, while pre-heated serum or fetal bovine serum does not.

Congruence of location-specific transcriptional programs in intestinal organoids during long-term culture

This study shows intestinal organoids maintain tissue-specific gene expression and location-specific transcriptional programs for at least 17 passages, outperforming a transformed cell line.