P. W. Finn

Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity

This study repurposes Hsp90 inhibitors as antimicrobials targeting bacterial two-component systems, finding that DPP analogues disrupt bacterial membranes and show antimicrobial activity against Gram-positive bacteria.

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival

This study shows that HPSE disrupts innate defense responses, promoting cell survival during HSV-1 infection by inhibiting cell-intrinsic defenses and facilitating host cell reprogramming.

Evaluating bacterial and functional diversity of human gut microbiota by complementary metagenomics and metatranscriptomics

The paper evaluates bacterial diversity and functional gene expression in the human gut microbiota using metagenomics and metatranscriptomics, showing that 52% of metagenomic genes are expressed and some low-abundance species are metabolically active.