Author

A. Moulana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:virus· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. M. Phillips· 4 shared M. M. Desai· 4 shared J. Chang· 3 shared T. Dupic· 3 shared A. A. Roffler· 2 shared A. J. Greaney· 2 shared J. D. Bloom· 2 shared K. R. Lawrence· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersEvolutionary Biology

A. M. Phillips

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Author profile →

4 papers

Recent·Most cited

The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution

A. Moulana, T. Dupic, A. M. Phillips, J. Chang, A. A. Roffler, A. J. Greaney, T. N. Starr, J. D. Bloom, M. M. Desai

The paper maps how mutations in the SARS-CoV-2 Omicron BA.1 RBD affect antibody binding affinity through systematic analysis of 32,768 genotypes against four monoclonal antibodies.

bioRxiv · Sep 13, 2022Evolutionary Biology

Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1

A. Moulana, T. Dupic, A. M. Phillips, J. Chang, S. Nieves, A. A. Roffler, A. J. Greaney, T. N. Starr, J. D. Bloom, M. M. Desai

This study identifies compensatory epistasis in SARS-CoV-2 Omicron BA.1 that maintains ACE2 affinity despite antibody-escape mutations.

bioRxiv · Jun 17, 2022Evolutionary Biology

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

A. M. Phillips, K. R. Lawrence, A. Moulana, T. Dupic, J. Chang, M. S. Johnson, I. Cvijovic, T. Mora, A. M. Walczak, M. M. Desai

This study measures binding affinity landscapes of two influenza bnAbs to understand their evolutionary pathways and how they acquire breadth.

bioRxiv · May 25, 2021Evolutionary Biology

Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

M. S. Johnson, S. Gopalakrishnan, J. Goyal, M. E. Dillingham, C. W. Bakerlee, P. T. Humphrey, T. Jagdish, E. R. Jerison, K. Kosheleva, K. R. Lawrence, J. Min, A. Moulana, A. M. Phillips, J. C. Piper, R. Purkanti, , M. M. Desai

This study tracks phenotypic and molecular evolution in 205 yeast populations over 10,000 generations, revealing patterns of declining adaptability, mutation accumulation, and genetic parallelism.

bioRxiv · Oct 9, 2020Evolutionary Biology