Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors
A. L. Casillas, S. S. Chauhan, R. K. Toth, A. G. Sainz, A. N. Clements, C. C. Jensen, P. R. Langlais, C. K. Miranti, A. E. Cress, N. A. Warfel
This study identifies PIM1 kinase as a regulator of HIF-1α stability and angiogenesis in solid tumors through direct phosphorylation at threonine 455.
bioRxiv · Mar 17, 2021Cancer Biology