C. K. Miranti

Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

This study identifies PIM1 kinase as a regulator of HIF-1α stability and angiogenesis in solid tumors through direct phosphorylation at threonine 455.

Notch3 promotes prostate cancer-induced bone lesion development via MMP3

This study shows Notch3 promotes osteoblastic bone lesions in prostate cancer by inhibiting osteoclasts and enhancing osteoblasts through MMP-3.