P. R. Langlais

ER structural remodeling requires TAK1/ATAT1-induced microtubule acetylation

The paper shows TAK1 activates TAT1 to acetylate microtubules, promoting ER tubulation and cell survival by downregulating BOK.

Identification of Mfn2-S249 as a Phosphoregulatory Switch of Mitochondrial Fusion Dynamics

The paper identifies Mfn2-S249 as a phosphoregulatory switch controlling mitochondrial fusion dynamics through TAK1-mediated phosphorylation, affecting mitochondrial morphology and energy homeostasis.

EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in developing neurons

This study identifies EVL's role in regulating dendritic filopodia morphology and dynamics through its interaction with MIM/MTSS1, promoting actin remodeling in developing neurons.

Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

This study identifies PIM1 kinase as a regulator of HIF-1α stability and angiogenesis in solid tumors through direct phosphorylation at threonine 455.

Discriminating changes in protein structure using PTAD conjugation to tyrosine

This study uses PTAD conjugation to tyrosine to distinguish conformational states of proteins by measuring PTAD labeling depth relative to the protein surface.