R. K. Toth

Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

This study identifies PIM1 kinase as a regulator of HIF-1α stability and angiogenesis in solid tumors through direct phosphorylation at threonine 455.

PIM Kinases Alter Mitochondrial Dynamics and Chemosensitivity in Lung Cancer

This study shows that PIM kinase inhibition increases mitochondrial fission and ROS, enhancing chemotherapy sensitivity in NSCLC.