A Type VI Secretion System in Burkholderia Species cenocepacia and orbicola Triggers Distinct Macrophage Death Pathways Independent of the Pyrin Inflammasome
N. A. Loeven, A. D. Reuven, A. P. McGee, C. Dabi, B. W. Mwaura, J. B. Bliska
This study shows that Burkholderia cenocepacia and orbicola trigger distinct macrophage death pathways, with cenocepacia using the caspase-11 inflammasome and orbicola using a TecA-dependent alternative pathway.
bioRxiv · Sep 28, 2023 · PreprintMicrobiology