J. B. Bliska

ExoS Effector in Pseudomonas aeruginosa Hyperactive Type III Secretion System Mutant Promotes Enhanced Plasma Membrane Rupture in Neutrophils

The paper shows that a hyperactive T3SS mutant of P. aeruginosa enhances neutrophil plasma membrane rupture via ExoS ADPRT activity, which is inhibited by glycine.

A Type VI Secretion System in Burkholderia Species cenocepacia and orbicola Triggers Distinct Macrophage Death Pathways Independent of the Pyrin Inflammasome

This study shows that Burkholderia cenocepacia and orbicola trigger distinct macrophage death pathways, with cenocepacia using the caspase-11 inflammasome and orbicola using a TecA-dependent alternative pathway.

Phosphoprotein Phosphatase Activity Positively Regulates Oligomeric Pyrin to Trigger Inflammasome Assembly in Phagocytes

This study identifies phosphoprotein phosphatase activity as a positive regulator of oligomeric pyrin, essential for inflammasome assembly in phagocytes.

Intestinal Bacteroides Modulates Systemic Inflammation and the Microbial Ecology in a Mouse Model of CF: Evidence for Propionate and other Short Chain Fatty Acids Reducing Systemic Inflammatory Cytokines

This study shows that Bacteroides in CF patients reduces systemic inflammation via propionate and alters microbial ecology in a mouse model of CF.

The Burkholderia cenocepacia type VI secretion system effector TecA is a virulence factor during lung infection

This paper demonstrates that TecA, a type VI secretion system effector of Burkholderia cenocepacia, acts as a virulence factor by exacerbating lung inflammation, weight loss, and lethality in a CF mouse model.

Precursor abundance influences divergent antigen specific CD8+ T cell responses after Yersinia pseudotuberculosis foodborne infection

This study shows that higher precursor abundance of YopE69-77-specific CD8+ T cells explains their dominance over OVA257-264-specific cells during Y. pseudotuberculosis infection.