Author

N. A. Loeven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

J. B. Bliska· 3 shared A. D. Reuven· 1 shared A. I. Perault· 1 shared A. N. Kettenbach· 1 shared A. P. McGee· 1 shared B. W. Mwaura· 1 shared C. A. Hodges· 1 shared C. Dabi· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

J. B. Bliska

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Author profile →

3 papers

Recent·Most cited

A Type VI Secretion System in Burkholderia Species cenocepacia and orbicola Triggers Distinct Macrophage Death Pathways Independent of the Pyrin Inflammasome

N. A. Loeven, A. D. Reuven, A. P. McGee, C. Dabi, B. W. Mwaura, J. B. Bliska

This study shows that Burkholderia cenocepacia and orbicola trigger distinct macrophage death pathways, with cenocepacia using the caspase-11 inflammasome and orbicola using a TecA-dependent alternative pathway.

bioRxiv · Sep 28, 2023 · PreprintMicrobiology

Phosphoprotein Phosphatase Activity Positively Regulates Oligomeric Pyrin to Trigger Inflammasome Assembly in Phagocytes

H. S. Malek, F. Magnotti, N. A. Loeven, J. M. Delgado, A. N. Kettenbach, T. Henry, J. B. Bliska

This study identifies phosphoprotein phosphatase activity as a positive regulator of oligomeric pyrin, essential for inflammasome assembly in phagocytes.

bioRxiv · Mar 23, 2022Immunology

The Burkholderia cenocepacia type VI secretion system effector TecA is a virulence factor during lung infection

N. A. Loeven, A. I. Perault, P. A. Cotter, C. A. Hodges, J. D. Schwartzman, T. H. Hampton, J. B. Bliska

This paper demonstrates that TecA, a type VI secretion system effector of Burkholderia cenocepacia, acts as a virulence factor by exacerbating lung inflammation, weight loss, and lethality in a CF mouse model.

bioRxiv · Jul 13, 2021Microbiology