Src-dependent DBL family members drive resistance to vemurafenib in human melanoma
C. R. Feddersen, J. L. Schillo, A. Varzavand, H. R. Vaughn, L. S. Wadsworth, A. P. Voigt, E. Y. Zhu, B. M. Jennings, S. A. Mullen, J. Bobera, J. D. Riordan, C. S. Stipp, A. J. Dupuy
This study identifies DBL family members as drivers of vemurafenib resistance in melanoma and shows that Src inhibition can block this resistance.
bioRxiv · Feb 26, 2019Cancer Biology