Proteolytic Activation of Human-specific Olduvai Domains by the Furin Protease
A. Pacheco, A. Issaian, J. Davis, N. Anderson, T. Nemkov, B. Vögeli, K. Hansen, J. Sikela
The paper shows human-specific Olduvai domains are cleaved by furin protease, suggesting they function as proproteins activated by this processing, linking their expansion to human brain evolution.
bioRxiv · Jul 6, 2021Evolutionary Biology