Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells
D. Hsu, J. Gao, N. Yamaguchi, A. Pinzaru, N. Mandayam, M. Liberti, S. Heissel, H. Alwaseem, S. Tavazoie, S. Tavazoie
This study shows that arginine limitation in colorectal cancer cells drives DNA sequence evolution away from arginine codons, leading to altered proteins.
bioRxiv · Jan 2, 2023 · PreprintCancer Biology