Author

H. Alwaseem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:metabolomics· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

H. Molina· 2 shared K. Birsoy· 2 shared N. Yamaguchi· 2 shared S. Heissel· 2 shared S. Tavazoie· 2 shared A. Khan· 1 shared A. Pinzaru· 1 shared B. Chait· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

H. Molina

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells

D. Hsu, J. Gao, N. Yamaguchi, A. Pinzaru, N. Mandayam, M. Liberti, S. Heissel, H. Alwaseem, S. Tavazoie, S. Tavazoie

This study shows that arginine limitation in colorectal cancer cells drives DNA sequence evolution away from arginine codons, leading to altered proteins.

bioRxiv · Jan 2, 2023 · PreprintCancer Biology

Integrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals

T. C. Kenny, A. Khan, Y. Son, L. Yue, S. Heissel, E. R. Gamazon, H. Alwaseem, R. K. Hite, K. Birsoy

The paper identifies FLVCR1 as essential for choline transport in mammals through integrative genetic analysis and functional studies.

bioRxiv · Oct 5, 2022Cell Biology

Analysis of the Mechanosensor Channel Functionality of TACAN

Y. Niu, X. Tao, G. Vaisey, P. D. B. Olinares, H. Alwaseem, B. Chait, R. MacKinnon

The paper investigates TACAN's functionality as a mechanosensitive ion channel and finds it does not exhibit mechanosensitive activity, instead showing structural features related to fatty acid elongase.

bioRxiv · Jun 11, 2021Biophysics

A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of bound metabolic mRNAs

X. Liu, H. Alwaseem, H. Molina, B. Tavora, S. Tavazoie

The paper identifies a tRNA fragment that promotes Nucleolin oligomerization and stabilizes metabolic mRNAs, enhancing breast cancer metastasis.

bioRxiv · Apr 26, 2021 · PreprintCancer Biology

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

J. Garcia-Bermudez, S. Prasad, L. Baudrier, M. A. Badgley, Y. Liu, K. La, M. Soula, R. T. Williams, N. Yamaguchi, R. F. Hwang, L. J. Taylor, E. De Stanchina, B. Rostandy, H. Alwaseem, H. Molina, , K. Birsoy

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

bioRxiv · Feb 2, 2021Cancer Biology

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

C. Kulkarni, S. M. Nadtochiy, L. Kennedy, J. Zhang, S. Chhim, H. Alwaseem, E. Murphy, D. Fu, P. S. Brookes

This study shows ALKBH7 regulates glyoxal metabolism, and its deficiency protects against necrosis and ischemia-reperfusion injury through hormetic signaling involving methylglyoxal stress.

bioRxiv · May 4, 2020Cell Biology