N. Yamaguchi

No Reliable Evidence Supports the Presence of Javan Tigers - Data Issues Related to the DNA Analysis of a Recent Hair Sample

The paper reanalyzes mtDNA data from a claimed Javan tiger hair sample and finds the sequences likely represent nuclear mitochondrial DNA with high mismatches, indicating unreliable data.

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

Genomic analysis supports Cape Lion population connectivity prior to colonial eradication and extinction

The paper analyzes genomic data from extinct Cape lions to show they were not genetically distinct from other African lions, challenging earlier claims of their uniqueness.

Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells

This study shows that arginine limitation in colorectal cancer cells drives DNA sequence evolution away from arginine codons, leading to altered proteins.

Ancient DNA Reveals China as a Historical Genetic Melting Pot in Tiger Evolution

This study uses ancient DNA to trace tiger evolution, revealing China as a genetic melting pot and resolving taxonomic disputes among tiger subspecies.

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levels

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

Lions and brown bears colonized North America in multiple synchronous waves of dispersal across the Bering Land Bridge

This study analyzes mitochondrial genomes of ancient brown bears and lions to show synchronous dispersal and extinction events across the Bering Land Bridge during the Pleistocene.

Removal of repressive histone marks creates epigenetic memory of recurring heat in Arabidopsis

The paper shows that JMJ proteins remove repressive histone marks in Arabidopsis, enabling epigenetic memory of heat exposure to improve heat tolerance.

Florigen family chromatin recruitment, competition and target genes

The paper shows TFL1 and FT antagonistically regulate floral fate through chromatin recruitment and competition, with LFY as a key target gene.

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and nucleotide biosynthesis under hypoxia

This study identifies PCK1 and DHODH as drivers of colorectal cancer liver metastasis under hypoxia by promoting nucleotide biosynthesis.