A. Porgador

The paper develops a method to predict response to anti-PD1 therapy by measuring PDL1 and PDL2 binding functionality, finding it more effective than protein expression alone.

This study shows that Fc-independent monoclonal antibodies can neutralize SARS-CoV-2 in mice, reducing viral load and preventing mortality without Fc-dependent effector functions.

This study uses a nanoengineered cell niche to investigate how spatial positioning of activating and inhibitory ligands affects NK cell signaling, finding that a 40 nm gap optimally inhibits NKG2D signaling via KIR2DL1.

This paper shows that NK cells modulate their cytotoxic activity in response to surface stiffness, with a bell-shaped response peak at ~few hundreds of kPa, and links this to DAP10 clustering and a catch-bond model.