B. Kaufman

TCA Cycle Dysfunction and Amino Acid Catabolism Drive Hepatic Steatosis in Mice with HFpEF

This study shows that TCA cycle dysfunction and amino acid catabolism in mice with HFpEF drive hepatic steatosis similar to human NAFLD.

Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional Adaptation

The paper maps chemoresistome dynamics in breast cancer patients to identify patient-specific resistance mechanisms and vulnerabilities.

Functional binding of PD1 ligands predicts response to anti-PD1 treatment in cancer patients

The paper develops a method to predict response to anti-PD1 therapy by measuring PDL1 and PDL2 binding functionality, finding it more effective than protein expression alone.

Liraglutide protects against diastolic dysfunction and improves ventricular protein translation

This study shows liraglutide reduces diastolic dysfunction in mice by enhancing cardiac protein translation and amino acid uptake, but also causes muscle mass loss.

An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma

The paper optimizes an automated high-throughput method for isolating cell-free mitochondrial and nuclear DNA from plasma, achieving 6-fold higher yields of mitochondrial DNA.