The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair
Y. S. Mardenborough, K. Nitsenko, C. Laffeber, C. Duboc, E. Sahin, A. Quessada-Vial, H. H. Winterwerp, T. K. Sixma, R. Kanaar, P. Friedhoff, T. R. Strick, J. H. Lebbink
The paper shows that the disordered linker regions of MutL enable bypass of roadblocks during DNA mismatch repair initiation, allowing incision at GATC sites.
bioRxiv · Nov 5, 2018Biochemistry