Author

E. Sahin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Catic· 2 shared N. Shroyer· 2 shared A. Engevik· 1 shared A. Groves· 1 shared A. Quessada-Vial· 1 shared B. C. Berk· 1 shared B. Saez· 1 shared B. Yurtsever· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

A. Catic

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Telomere dysfunction impairs intestinal differentiation andpredisposes to diet-induced colitis

M. Engevik, L. Guo, W.-S. Song, C. Chronowski, V. Akhanov, N. Bosquez, A. Engevik, N. Oezguen, C. Coarfa, N. Putluri, A. Catic, J. Baur, M. Finegold, N. Shroyer, J. Gu, , E. Sahin

This study shows that telomere shortening impairs intestinal differentiation, leading to barrier defects and diet-induced colitis through microbiome modulation and nutrient flux.

bioRxiv · Jul 14, 2022 · PreprintCell Biology

Cyclophilin A regulates protein phase separation and mitigates haematopoietic stem cell aging

L. Maneix, P. Iakova, S. E. Moree, J. C. K. King, D. B. Sykes, C. T. Hill, B. Saez, E. Spooner, D. S. Krause, E. Sahin, B. C. Berk, D. T. Scadden, A. Catic

This study identifies Cyclophilin A as a key regulator of protein phase separation and shows its role in mitigating haematopoietic stem cell aging.

bioRxiv · Feb 24, 2021Cell Biology

Non-clinical safety profile and pharmacodynamics of two formulations of the anti-sepsis drug candidate Rejuveinix

F. Uckun, c. orhan, J. Powell, E. Sahin, I. Ozercan, M. Volk, K. Sahin

This study shows two Rejuveinix formulations have a favorable safety profile in rats and similarly increase antioxidant levels in tissues, indicating bioequivalence.

bioRxiv · Jan 3, 2021Pharmacology & Toxicology

SARS-CoV-2 Isolation and Propagation from Turkish COVID-19 patients

C. Tastan, B. Yurtsever, G. Sir, D. Dilek Kancagi, S. Demir, S. Abanuz, U. Seyis, M. Yildirim, R. Kuzay, O. Elibol, S. Arbak, M. Acikel Elmas, S. Birdogan, E. Sahin, O. Ozcan, , E. Ovali

The paper isolates and characterizes SARS-CoV-2 from Turkish COVID-19 patients, providing methodology for virus propagation and cell culture tropism.

bioRxiv · Apr 23, 2020Microbiology

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

Y. S. Mardenborough, K. Nitsenko, C. Laffeber, C. Duboc, E. Sahin, A. Quessada-Vial, H. H. Winterwerp, T. K. Sixma, R. Kanaar, P. Friedhoff, T. R. Strick, J. H. Lebbink

The paper shows that the disordered linker regions of MutL enable bypass of roadblocks during DNA mismatch repair initiation, allowing incision at GATC sites.

bioRxiv · Nov 5, 2018Biochemistry

Gfi1-expressing Paneth cells revert to stem cells following intestinal injury

M.-S. Chen, Y.-H. Lo, J. Butkus, W. Zou, Y.-J. Tseng, H.-I. Jen, S. Patel, A. Groves, M. Estes, E. Sahin, M. Frey, P. Dempsey, N. Shroyer

This study shows that Gfi1-expressing secretory cells can revert to stem cells after intestinal injury, with PI3kinase/AKT and WNT signaling enhancing this process.

bioRxiv · Jul 16, 2018 · PreprintCell Biology