Author

C. Laffeber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

J. Lebbink· 2 shared P. Friedhoff· 2 shared R. Kanaar· 2 shared A. Quessada-Vial· 1 shared C. Duboc· 1 shared E. Sahin· 1 shared G. Brouwer· 1 shared H. H. Winterwerp· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

J. Lebbink

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Author profile →

3 papers

Recent·Most cited

DNA mismatch and damage detection using a FRET-based assay for monitoring the loading of multiple MutS sliding clamps

V. Kunetsky, O. Storozhuk, G. Brouwer, C. Laffeber, M. S. Dillingham, J. Lebbink, P. Friedhoff

The paper develops a FRET-based assay using MutS to detect DNA mismatches and damage by monitoring ATP-dependent loading of multiple MutS sliding clamps.

bioRxiv · Jul 23, 2021 · PreprintBiochemistry

Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants

C. Laffeber, K. de Koning, R. Kanaar, J. Lebbink

The paper experimentally evaluates the receptor binding affinity of SARS-CoV-2 variants and identifies mutations affecting viral transmission and immune evasion.

bioRxiv · Feb 22, 2021Biochemistry

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

Y. S. Mardenborough, K. Nitsenko, C. Laffeber, C. Duboc, E. Sahin, A. Quessada-Vial, H. H. Winterwerp, T. K. Sixma, R. Kanaar, P. Friedhoff, T. R. Strick, J. H. Lebbink

The paper shows that the disordered linker regions of MutL enable bypass of roadblocks during DNA mismatch repair initiation, allowing incision at GATC sites.

bioRxiv · Nov 5, 2018Biochemistry