R. Kanaar

DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces

This paper explains how BRCA2's FxxA and FxPP motifs bind to DMC1 and RAD51 via distinct interfaces, stabilizing recombinase filaments and explaining functional differences between these proteins.

BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination

The paper shows that BRME1 disrupts the HSF2BP-BRCA2 ring complex, preventing BRCA2 degradation and promoting homologous recombination in meiosis.

Distinct mobility patterns of BRCA2 molecules at DNA damage sites

This study quantifies BRCA2 mobility patterns at DNA damage sites using advanced microscopy, revealing immobile and subdiffusive motions that may enhance repair efficiency.

Functional single cell proteomic profiling of cells with abnormal DNA damage response dynamics

The paper develops FUNpro, a functional single-cell proteomic profiling method, to link proteomes with dynamic cellular phenotypes, identifying PDS5A and PGAM5 in DDR survival.

Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants

The paper experimentally evaluates the receptor binding affinity of SARS-CoV-2 variants and identifies mutations affecting viral transmission and immune evasion.

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

The paper shows that the disordered linker regions of MutL enable bypass of roadblocks during DNA mismatch repair initiation, allowing incision at GATC sites.