MYPT1 O-GlcNAc modification controls the sensitivity of fibroblasts to sphingosine-1-phosphate mediated cellular contraction
N. J. Pedowitz, A. R. Batt, N. Darabedian, M. R. Pratt
This study shows that MYPT1 O-GlcNAc modification regulates fibroblast sensitivity to S1P-induced contraction by inhibiting MYPT1 phosphorylation and MLC dephosphorylation, impacting wound healing.
bioRxiv · Jun 24, 2020 · PreprintCell Biology