Author

M. R. Pratt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

A. T. Balana· 2 shared N. Darabedian· 2 shared N. J. Pedowitz· 2 shared A. Anand· 1 shared A. Javed· 1 shared A. R. Batt· 1 shared A.-L. Mahul-Mellier· 1 shared B. A. Nguyen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

A. T. Balana

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

A. T. Balana, A.-L. Mahul-Mellier, B. A. Nguyen, M. Horvath, A. Javed, E. R. Hard, Y. Jasiqi, P. Singh, S. Afrin, R. Pedretti, V. Singh, V. M.-Y. Lee, K. C. Luk, L. Saelices, H. A. Lashuel, M. R. Pratt

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

bioRxiv · Mar 7, 2023 · PreprintBiochemistry

Exo-enzymatic addition of diazirine-modified sialic acid to cell surfaces enables photocrosslinking of glycoproteins

N. Yarravarapu, R. S. R. Konada, N. Darabedian, N. J. Pedowtiz, S. N. Krishnamurthy, M. R. Pratt, J. J. Kohler

The paper introduces an exo-enzymatic method to add diazirine-modified sialic acid to cell surfaces, enabling UV-induced crosslinking of glycoproteins involved in glycan-mediated interactions.

bioRxiv · Oct 7, 2021Biochemistry

Hyaluronic Acid Fuels Pancreatic Cancer Growth

P. K. Kim, C. J. Halbrook, S. A. Kerk, S. Wisner, D. M. Kremer, P. Sajjakulnukit, S. W. Hou, G. Thurston, A. Anand, L. Yan, L. Salamanca-Cardona, S. D. Welling, L. Zhang, M. R. Pratt, K. R. Keshari, , C. A. Lyssiotis

This study shows hyaluronic acid fuels pancreatic cancer metabolism by bypassing GFAT1 via the GlcNAc salvage pathway, enabling proliferation in nutrient-starved conditions.

bioRxiv · Sep 14, 2020 · PreprintCancer Biology

MYPT1 O-GlcNAc modification controls the sensitivity of fibroblasts to sphingosine-1-phosphate mediated cellular contraction

N. J. Pedowitz, A. R. Batt, N. Darabedian, M. R. Pratt

This study shows that MYPT1 O-GlcNAc modification regulates fibroblast sensitivity to S1P-induced contraction by inhibiting MYPT1 phosphorylation and MLC dephosphorylation, impacting wound healing.

bioRxiv · Jun 24, 2020 · PreprintCell Biology

O-GlcNAcylation of small heat shock proteins enhances their anti-amyloid chaperone activity

A. T. Balana, P. M. Levine, S. Mukherjee, N. J. Pedowitz, S. P. Moon, T. T. Takahashi, C. F. W. Becker, M. R. Pratt

This study shows that O-GlcNAcylation enhances the anti-amyloid activity of small heat shock proteins by modulating their interaction with substrates.

bioRxiv · Dec 10, 2019Biochemistry