Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation
A. R. Camacho-Zarco, L. Yu, T. Krischuns, S. Dedeoglu, D. Maurin, G. Bouvignies, T. Crepin, R. W. H. Ruigrok, S. Cusack, N. Naffakh, M. Blackledge
This study identifies how the E627K mutation in avian influenza polymerase enables multivalent colocalization with ANP32A and nucleoprotein in human cells, facilitating viral adaptation.
bioRxiv · Jul 8, 2023 · PreprintBiochemistry