S. Cusack

Structures of the Tilapia Lake Virus replication complex show that ANP32 is a host factor for replication across the Articulavirales order

This study shows that ANP32 is a conserved host factor for viral replication in the Articulavirales order, using structural and biochemical analyses of TiLV and its interaction with ANP32.

Mechanism of Co-Transcriptional Cap-Snatching by Influenza Polymerase

This study reveals the molecular mechanisms of cap-snatching by influenza polymerase using cryo-EM structures of FluPol bound to Pol II and DSIF.

Structural basis for the synergistic assembly of the snRNA export complex

This study presents the cryo-EM structure of the snRNA export complex and shows how PHAX synergistically binds components to facilitate snRNA export.

Structure of the Tilapia lake virus nucleoprotein bound to RNA

The paper describes the cryo-EM structure of TiLV nucleoprotein bound to RNA, revealing its RNA-binding mechanism and structural conservation across Articulavirales.

Structures of influenza A and B replication complexes explain avian to human host adaption and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.

The paper reveals ANP32's role as an electrostatic chaperone stabilizing influenza polymerase complexes, explaining host adaptation and providing structural insights into replication complexes.

High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit

The paper presents a high-resolution structure of influenza polymerase showing the role of a conserved dibasic motif in replication initiation.

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

This study shows that host RNA polymerase II's C-terminal domain, along with ANP32, enhances influenza virus polymerase replication activity, suggesting host RNAP II anchors viral transcription and replication.

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation

This study identifies how the E627K mutation in avian influenza polymerase enables multivalent colocalization with ANP32A and nucleoprotein in human cells, facilitating viral adaptation.

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

Backtracking of influenza polymerase upon consecutive incorporation of nucleoside analogue T1106 directly observed by high resolution cryo-electron microscopy

This study uses cryo-EM to observe how influenza polymerase backtracks after incorporating T1106-MP nucleotides, revealing structural changes that lead to chain termination.

Type B and Type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

This study compares the binding interfaces of influenza B and A polymerases to the host RNA polymerase II CTD, revealing distinct evolutionary adaptations for host range.

NCBP3 is a productive mRNP component

This study identifies NCBP3 as a component of an alternative CBC complex that interacts with EJC and TREX, supporting mRNA processing and nuclear export.

Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

This study presents the cryo-EM structures of La Crosse virus polymerase in pre-initiation and elongation states, revealing conformational changes important for transcription.