N. Naffakh

Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.

A polarized cell system amenable to subcellular resolution imaging of influenza virus infection

This paper describes a 3D cell culture method to study influenza virus infection in polarized cells with subcellular resolution.

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

This study shows that host RNA polymerase II's C-terminal domain, along with ANP32, enhances influenza virus polymerase replication activity, suggesting host RNAP II anchors viral transcription and replication.

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation

This study identifies how the E627K mutation in avian influenza polymerase enables multivalent colocalization with ANP32A and nucleoprotein in human cells, facilitating viral adaptation.

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

Type B and Type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

This study compares the binding interfaces of influenza B and A polymerases to the host RNA polymerase II CTD, revealing distinct evolutionary adaptations for host range.

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

The paper develops a sensitive cell-based luciferase assay for high-throughput screening of SARS-CoV-2 nsp5/3CLpro inhibitors and identifies four effective compounds.