T. Crepin

Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core

This paper identifies an intracellular nanobody that inhibits influenza A virus RNA-polymerase by blocking PA-PB1 dimer nuclear import, showing potential for antiviral development.

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation

This study identifies how the E627K mutation in avian influenza polymerase enables multivalent colocalization with ANP32A and nucleoprotein in human cells, facilitating viral adaptation.