Author

A. R. Gooding

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

T. R. Cech· 4 shared V. Kasinath· 2 shared W. O. Hemphill· 2 shared C. I. Sousa· 1 shared J. J. Song· 1 shared J. L. Rinn· 1 shared J. Song· 1 shared L. I. Jansson-Fritzberg· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

T. R. Cech

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4 papers

Recent·Most cited

Structural basis for inactivation of PRC2 by G-quadruplex RNA

J. Song, A. R. Gooding, W. O. Hemphill, V. Kasinath, T. R. Cech

The paper presents a cryo-EM structure of PRC2 bound to G-quadruplex RNA, revealing how RNA inhibits PRC2 by promoting dimerization and blocking DNA interaction.

bioRxiv · Feb 6, 2023Biochemistry

PRC2 direct transfer from G-quadruplex RNA to dsDNA: Implications for RNA-binding chromatin modifiers

W. O. Hemphill, R. Fenske, A. R. Gooding, T. R. Cech

This study reveals a direct transfer mechanism by which PRC2 exchanges RNA and DNA/nucleosome in its binding site, reconciling conflicting in vitro and in vivo findings on RNA's role in regulating PRC2 activity.

bioRxiv · Nov 30, 2022 · PreprintBiophysics

DNMT1 inhibition by pUG-fold quadruplex RNA

L. I. Jansson-Fritzberg, C. I. Sousa, M. J. Smallegan, J. J. Song, A. R. Gooding, V. Kasinath, J. L. Rinn, T. R. Cech

This study shows that DNMT1 interacts with pUG-fold RNA, which inhibits its activity by blocking DNA binding.

bioRxiv · Oct 14, 2022Biochemistry

Regulation of histone methylation by automethylation of PRC2

X. Wang, Y. Long, R. D. Paucek, A. R. Gooding, T. Lee, T. R. Cech

This study identifies EZH2 automethylation as a regulatory mechanism that modulates PRC2 histone methyltransferase activity.

bioRxiv · Jun 8, 2018Biochemistry