W. O. Hemphill

Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms

This study investigates the DNA and RNA binding kinetics of ERα and Sox2, revealing distinct multiphasic binding mechanisms with ER showing novel triphasic association behavior.

Structural basis for inactivation of PRC2 by G-quadruplex RNA

The paper presents a cryo-EM structure of PRC2 bound to G-quadruplex RNA, revealing how RNA inhibits PRC2 by promoting dimerization and blocking DNA interaction.

RNA- and DNA-binding proteins generally exhibit direct transfer of polynucleotides: Implications for target site search

The paper demonstrates that RNA- and DNA-binding proteins can directly transfer polynucleotides, enabling one-dimensional target site search and suggesting regulated complex lifetimes in vivo.

PRC2 direct transfer from G-quadruplex RNA to dsDNA: Implications for RNA-binding chromatin modifiers

This study reveals a direct transfer mechanism by which PRC2 exchanges RNA and DNA/nucleosome in its binding site, reconciling conflicting in vitro and in vivo findings on RNA's role in regulating PRC2 activity.

Kleptocytosis: Comparative Proteomics and Functional Imaging Show Varroa destructor Co-opts Intact Host Proteins for Rapid Development and Reproduction

This paper shows Varroa destructor steals intact host proteins for rapid development and reproduction, describing this as 'kleptocytosis'.

A TREX1 model reveals double-strand DNA preference and inter-protomer regulation

This study investigates TREX1 exonuclease activity, revealing its preference for double-strand DNA and inter-protomer regulation through biochemical assays, simulations, and modeling.