Author

A. R. Loftis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

B. L. Pentelute· 3 shared A. Loas· 2 shared G. Zhang· 2 shared A. J. Quartararo· 1 shared A. Saebi· 1 shared B. E. Poulsen· 1 shared C. Backlund· 1 shared C. K. Schissel· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBioengineering

B. L. Pentelute

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3 papers

Recent·Most cited

Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides

A. R. Loftis, G. Zhang, C. Backlund, A. J. Quartararo, N. Pishesha, C. K. Schissel, D. Garafola, A. Loas, R. J. Collier, H. Ploegh, D. J. Irvine, B. L. Pentelute

The paper identifies a D-peptide that targets murine erythrocytes and reduces anti-drug antibody responses when conjugated to therapeutic proteins.

bioRxiv · Jul 15, 2020 · PreprintBioengineering

Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD

G. Zhang, S. Pomplun, A. R. Loftis, X. Tan, A. Loas, B. L. Pentelute

This study investigates ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD using molecular dynamics simulations and peptide synthesis, finding that a 23-mer peptide fragment binds with micromolar affinity to insect-derived RBD but not HEK-expressed RBD.

bioRxiv · Mar 19, 2020 · PreprintBioengineering

Mutations in pmrB confer cross-resistance to the LptD inhibitor POL7080 and colistin in Pseudomonas aeruginosa

K. P. Romano, T. Warrier, B. E. Poulsen, P. H. Nguyen, A. R. Loftis, A. Saebi, B. L. Pentelute, D. T. Hung

The paper identifies mutations in pmrB conferring cross-resistance to POL7080 and colistin in Pseudomonas aeruginosa by linking resistance mechanisms to lipid A modifications.

bioRxiv · Mar 8, 2019Microbiology