Author

A. R. Mack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

R. A. Bonomo· 2 shared S. Haider· 2 shared A. J. Mulholland· 1 shared A. M. Hujer· 1 shared A. S. F. Oliveira· 1 shared C. L. Tooke· 1 shared C. R. Bethel· 1 shared E. Olehnovics· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

R. A. Bonomo

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

{Omega}-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

S. Chen, A. R. Mack, A. M. Hujer, C. R. Bethel, R. A. Bonomo, S. Haider

This study investigates how {Omega}-loop mutations in PDC-3 β-lactamase affect its active site dynamics and catalytic activity through molecular simulations.

eLife · Jan 21, 2026Peer-reviewedBiophysics

Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics

I. Galdadas, S. Qu, A. S. F. Oliveira, E. Olehnovics, A. R. Mack, M. F. Mojica, P. K. Agarwal, C. L. Tooke, F. L. Gervasio, J. Spencer, R. A. Bonomo, A. J. Mulholland, S. Haider

This study identifies allosteric communication pathways in Class A β-lactamases using molecular dynamics simulations, showing how amino acid substitutions affect enzyme activity and antibiotic resistance.

bioRxiv · Dec 30, 2020Biophysics