I. Galdadas

The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

This study identifies how the T766M-EGFR mutation promotes tumor growth by utilizing new oligomer assembly mechanisms in ligand-free EGFR.

The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm

This study screens 1,280 drugs on human sperm Ca2+ channels, finding 53% of steroids increase [Ca2+]i and inhibit progesterone-induced Ca2+ influx, with some activating CatSper and affecting sperm motility and acrosomal exocytosis.

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

The paper determines the structure and activation mechanism of the MKK6-p38α complex using cryo-EM and MD simulations, revealing how phosphorylation and interactions drive MAPK specificity.

Revealing druggable cryptic pockets in the Nsp-1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

This study identifies druggable pockets in Nsp1 of SARS-CoV-2 and other β-coronaviruses using simulations and crystallography, showing potential for new inhibitors.

Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics

This study identifies allosteric communication pathways in Class A β-lactamases using molecular dynamics simulations, showing how amino acid substitutions affect enzyme activity and antibiotic resistance.