Author

M. F. Mojica

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:statistical model· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

R. A. Bonomo· 3 shared S. Haider· 3 shared J. Gu· 2 shared Z. Zhao· 2 shared A. J. Mulholland· 1 shared A. J. Vila· 1 shared A. M. Hujer· 1 shared A. R. Mack· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

R. A. Bonomo

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3 papers

Recent·Most cited

Deciphering the co-evolutionary dynamics of L2 β-lactamases via Deep learning

Y. Zhu, J. Gu, Z. Zhao, A. W. E. Chan, M. F. Mojica, A. M. Hujer, R. A. Bonomo, S. Haider

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.

bioRxiv · Jan 14, 2024 · PreprintMicrobiology

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

Z. Zhao, X. Shen, S. Chen, J. Gu, H. Wang, M. F. Mojica, M. Samanta, D. Bhowmik, A. J. Vila, R. A. Bonomo, S. Haider

The paper investigates how gating interactions between loops in the L1 metallo-β-lactamase affect active site conformational changes and identifies key residues critical for enzyme activity.

bioRxiv · Oct 25, 2022Biophysics

Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics

I. Galdadas, S. Qu, A. S. F. Oliveira, E. Olehnovics, A. R. Mack, M. F. Mojica, P. K. Agarwal, C. L. Tooke, F. L. Gervasio, J. Spencer, R. A. Bonomo, A. J. Mulholland, S. Haider

This study identifies allosteric communication pathways in Class A β-lactamases using molecular dynamics simulations, showing how amino acid substitutions affect enzyme activity and antibiotic resistance.

bioRxiv · Dec 30, 2020Biophysics