Probiotic-guided CAR-T cells for universal solid tumor targeting
R. L. Vincent, C. Gurbatri, A. Redenti, C. Coker, N. Arpaia, T. Danino
This paper develops probiotic-guided CAR-T cells (ProCARs) that use synthetic antigens produced by tumor-colonizing bacteria to enhance T cell activation and tumor lysis in xenograft models.
bioRxiv · Oct 10, 2021 · PreprintBioengineering