T. Danino

Tumor-selective treatment of metastatic pancreatic cancer with an engineered, probiotic living drug

This study engineers a probiotic bacteria to selectively target pancreatic cancer, improving survival and modulating the tumor microenvironment.

Colorectal cancer detection and treatment with engineered probiotics

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

Engineered bacteria recruit and orchestrate anti-tumor immunity

The paper engineers bacteria to release chemokines that recruit immune cells into tumors, enhancing anti-tumor immunity in mouse models.

A deep learning pipeline for segmentation of Proteus mirabilis colony patterns

This paper develops a deep learning pipeline to segment macroscopic colony patterns of Proteus mirabilis, achieving high accuracy in identifying colony boundaries and internal ring structures.

Probiotic-guided CAR-T cells for universal solid tumor targeting

This paper develops probiotic-guided CAR-T cells (ProCARs) that use synthetic antigens produced by tumor-colonizing bacteria to enhance T cell activation and tumor lysis in xenograft models.

A spatial cell culture model for predicting chemotherapy dosing strategies

The paper develops a 2D spatial cell culture model to predict optimal chemotherapy dosing strategies by tracking tumor cell dynamics and building mathematical models of chemosensitive and chemoresistant populations.