Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands
F. M. Heydenreich, B. Plouffe, A. Rizk, D. Milic, J. Zhou, B. Breton, C. Le Gouill, A. Inoue, M. Bouvier, D. Veprintsev
The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.
bioRxiv · Jan 28, 2021 · PreprintPharmacology & Toxicology