Author

D. Veprintsev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

B. Plouffe· 2 shared C. Le Gouill· 2 shared D. A. Sykes· 2 shared M. Bouvier· 2 shared A. Inoue· 1 shared A. Morales-Pastor· 1 shared A. Rizk· 1 shared A. Rufer· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

B. Plouffe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

A. Morales-Pastor, T. Miljus, T. M. Stepniewski, V. Ledesma, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

bioRxiv · Feb 27, 2024 · PreprintCell Biology

Probing drug-target engagement of soluble Gαi1 protein using the SolThermoBRET thermal shift assay

O. Brod, D. Plevako, T. Perera, P. Hompluem, E. J. Koers, M. Hilbert, D. A. Sykes, D. Veprintsev

This paper introduces a high-throughput BRET-based thermal shift assay to measure protein stability and ligand interactions with Gi1 protein without purification.

bioRxiv · Feb 15, 2024 · PreprintBiophysics

Agonist efficacy at the B2AR is driven by agonist-induced differences in receptor affinity for the Gs protein, not ligand binding kinetics.

C. R. Harwood, D. A. Sykes, T. Redfern-Nichols, G. Ladds, S. J. Briddon, D. Veprintsev

This study shows that agonist efficacy at the {beta}2AR is determined by differences in receptor affinity for Gs protein, not ligand binding kinetics.

bioRxiv · Jan 5, 2024 · PreprintPharmacology & Toxicology

Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands

F. M. Heydenreich, B. Plouffe, A. Rizk, D. Milic, J. Zhou, B. Breton, C. Le Gouill, A. Inoue, M. Bouvier, D. Veprintsev

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

bioRxiv · Jan 28, 2021 · PreprintPharmacology & Toxicology