Author

C. Le Gouill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Bouvier· 5 shared B. Breton· 2 shared B. Plouffe· 2 shared D. Veprintsev· 2 shared F. M. Heydenreich· 2 shared T. Miljus· 2 shared U. Grether· 2 shared W. Guba· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersPharmacology & Toxicology

M. Bouvier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

A. Morales-Pastor, T. Miljus, T. M. Stepniewski, V. Ledesma, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

bioRxiv · Feb 27, 2024 · PreprintCell Biology

The G protein-coupled receptor TBXA2R activates ERMs to control cell motility and invasion of triple-negative breast cancer cells.

K. Leguay, O. Naffati, Y. Y. He, M. Rogue, C. Tesniere, M. Gombos, H. Kuasne, L. Gaboury, C. Le Gouill, S. Meloche, M. Bouvier, S. Carreno

bioRxiv · Mar 28, 2023 · PreprintCancer Biology

Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands

F. M. Heydenreich, B. Plouffe, A. Rizk, D. Milic, J. Zhou, B. Breton, C. Le Gouill, A. Inoue, M. Bouvier, D. Veprintsev

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

bioRxiv · Jan 28, 2021 · PreprintPharmacology & Toxicology

Diverse chemotypes drive biased signaling by cannabinoid receptors

T. Miljus, F. M. Heydenreich, T. Gazzi, A. Kimbara, M. Rogers-Evans, M. Nettekoven, E. Zirwes, A. Osterwald, A. C. Rufer, C. Ullmer, W. Guba, C. Le Gouill, J. Fingerle, M. Nazare, U. Grether, , D. B. Veprintsev

This study identifies chemotype-specific biased signaling in cannabinoid receptors by analyzing ligand-induced signaling cascades.

bioRxiv · Nov 9, 2020 · PreprintPharmacology & Toxicology

Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

C. Avet, A. Mancini, B. Breton, C. Le Gouill, A. S. Hauser, C. Normand, H. Kobayashi, F. Gross, M. Hogue, V. Lukasheva, S. St-Onge, M. Carrier, M. Heroux, S. Morissette, E. Fauman, , M. Bouvier

The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.

bioRxiv · Apr 20, 2020Pharmacology & Toxicology