Author

F. M. Heydenreich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Bouvier· 3 shared A. Inoue· 2 shared B. K. Kobilka· 2 shared C. Le Gouill· 2 shared D. B. Veprintsev· 2 shared A. C. Rufer· 1 shared A. Kimbara· 1 shared A. Osterwald· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersPharmacology & Toxicology

M. Bouvier

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Author profile →

5 papers

Recent·Most cited

Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics

J. Janetzko, R. Kise, B. Barsi-Rhyne, D. H. Siepe, F. M. Heydenreich, M. Masureel, K. Kawakami, K. C. Garcia, M. Von Zastrow, A. Inoue, B. K. Kobilka

This study identifies membrane phosphoinositides as regulators of GPCR-arrestin complex dynamics, showing they stabilize complexes and enable temporal control of receptor signaling and recycling.

bioRxiv · Oct 9, 2021Biochemistry

Dissecting the allosteric networks governing agonist efficacy and potency in G protein-coupled receptors

F. M. Heydenreich, M. Marti-Solano, M. Sandhu, B. K. Kobilka, M. Bouvier, M. M. Babu

The paper integrates residue-level pharmacology data with structural contact data to uncover allosteric networks that govern ligand efficacy and potency in GPCRs.

bioRxiv · Sep 14, 2021Biochemistry

Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands

F. M. Heydenreich, B. Plouffe, A. Rizk, D. Milic, J. Zhou, B. Breton, C. Le Gouill, A. Inoue, M. Bouvier, D. Veprintsev

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

bioRxiv · Jan 28, 2021 · PreprintPharmacology & Toxicology

Diverse chemotypes drive biased signaling by cannabinoid receptors

T. Miljus, F. M. Heydenreich, T. Gazzi, A. Kimbara, M. Rogers-Evans, M. Nettekoven, E. Zirwes, A. Osterwald, A. C. Rufer, C. Ullmer, W. Guba, C. Le Gouill, J. Fingerle, M. Nazare, U. Grether, , D. B. Veprintsev

This study identifies chemotype-specific biased signaling in cannabinoid receptors by analyzing ligand-induced signaling cascades.

bioRxiv · Nov 9, 2020 · PreprintPharmacology & Toxicology

Functional solubilisation of the β2-adrenoceptor (β2AR) using Diisobutylene maleic acid (DIBMA).

C. R. Harwood, D. A. Sykes, B. Hoare, F. M. Heydenreich, R. Uddin, D. R. Poyner, S. J. Briddon, D. B. Veprintsev

This paper demonstrates the functional solubilisation of the β2-adrenoceptor using DIBMA, showing improved thermal stability compared to detergent-based methods.

bioRxiv · Jun 29, 2020Biochemistry