Collagen density regulates the activity of tumor-infiltrating T cells
D. E. Kuczek, A. M. Hvid Larsen, M. Carretta, A. Kalvisa, M. S. Siersbaek, A. M. Carnaz Simoes, A. Roslind, L. H. Engelholm, M. Donia, I. M. Svane, P. t. Straten, L. Grontved, D. H. Madsen
This study shows that high collagen density in tumors reduces T cell proliferation and cytotoxicity, while increasing regulatory T cells, suggesting collagen density modulates T cell function in the tumor microenvironment.
bioRxiv · Dec 12, 2018Immunology