Author

I. M. Svane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Donia· 2 shared A. Borch· 1 shared A. Draghi· 1 shared A. Gokuldass· 1 shared A. K. Bentzen· 1 shared A. Kalvisa· 1 shared A. M. Carnaz Simoes· 1 shared A. M. Hvid Larsen· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

M. Donia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification and characterization of neoantigen-reactive CD8+ T cells following checkpoint blockade therapy in a pan-cancer setting

K. H. Moss, U. K. Hansen, V. A. B. De Lima, A. Borch, E. S. Marquez, A.-m. Bjerregaard, O. Oestrup, A. K. Bentzen, A. M. Marquard, M. Kadivar, I. M. Svane, U. Lassen, S. R. Hadrup

The paper detects neoantigen-reactive CD8+ T cells in tumor biopsies and peripheral blood post-checkpoint blockade therapy and identifies peptide hydrophobicity and treatment-induced phenotypes as factors influencing their response.

bioRxiv · Mar 17, 2024 · PreprintImmunology

Escape from nonsense mediated decay associates with anti-tumor immunogenicity

K. Litchfield, J. Reading, E. Lim, H. Xu, P. Liu, M. Al-Bakir, S. Wong, A. Rowan, S. Funt, T. Merghoub, M. Lauss, I. M. Svane, G. Jonsson, J. Herrero, J. Larkin, , C. Swanton

This study identifies NMD-escape fs-indels as a biomarker associated with improved response to immunotherapy in melanoma patients.

bioRxiv · Nov 14, 2019Cancer Biology

Collagen density regulates the activity of tumor-infiltrating T cells

D. E. Kuczek, A. M. Hvid Larsen, M. Carretta, A. Kalvisa, M. S. Siersbaek, A. M. Carnaz Simoes, A. Roslind, L. H. Engelholm, M. Donia, I. M. Svane, P. t. Straten, L. Grontved, D. H. Madsen

This study shows that high collagen density in tumors reduces T cell proliferation and cytotoxicity, while increasing regulatory T cells, suggesting collagen density modulates T cell function in the tumor microenvironment.

bioRxiv · Dec 12, 2018Immunology

Differential effects of corticosteroids and anti-TNF on tumor-specific immune responses - implications for the management of irAEs

A. Draghi, T. H. Borch, H. D. Radic, C. A. Chamberlain, A. Gokuldass, I. M. Svane, M. Donia

This study compares the effects of corticosteroids and anti-TNF on tumor-specific TILs in vitro, finding that corticosteroids significantly impair TIL activity while anti-TNF has a minor effect.

bioRxiv · Oct 8, 2018Cancer Biology