Author

A. Roulston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Veloso· 2 shared C. Bernier· 2 shared M. Zinda· 2 shared S. Fournier· 2 shared A. Alvarez-Quilon· 1 shared A. Bonneau Fortin· 1 shared A. Singhania· 1 shared A. Skeldon· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

A. Veloso

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2 papers

Recent·Most cited

Guiding ATR and PARP inhibitor combinations with chemogenomic screens

M. Zimmermann, C. Bernier, B. Kaiser, S. Fournier, L. Li, J. Desjardin, A. Skeldon, V. Rimkunkas, A. Veloso, J. T. Young, A. Roulston, M. Zinda

This study identifies genetic alterations that enhance the efficacy of ATR and PARP inhibitor combinations while reducing toxicity through CRISPR screens and mechanistic analysis.

bioRxiv · Dec 13, 2021Cancer Biology

CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition

D. Gallo, J. T. F. Young, J. Fourtounis, G. Martino, A. Alvarez-Quilon, C. Bernier, N. M. Duffy, R. Papp, A. Roulston, R. Stocco, J. Szychowski, A. Veloso, H. Alam, P. S. Baruah, A. Bonneau Fortin, , D. Durocher

The paper identifies PKMYT1 as a therapeutic target for CCNE1-amplified cancers, showing that its inhibition leads to synthetic lethality and tumor regression in combination with gemcitabine.

bioRxiv · Apr 8, 2021Cancer Biology