CXCR4 allows T cell acute lymphoblastic leukemia to escape from JAK1/2 and BCL2 inhibition through CNS infiltration
K. L. Walker, S. P. Rinella, N. J. Hess, D. P. Turicek, S. A. Kabakov, F. Zhu, M. N. Bouchlaka, S. L. Olson, M. M. Cho, A. E. Quamine, A. S. Feils, T. B. Gavcovich, L. Rui, C. M. Capitini
This study shows that combining JAK1/2 and BCL2 inhibitors in T-ALL leads to CNS infiltration, which is reduced by adding a CXCR4 inhibitor.
bioRxiv · Mar 6, 2021Cancer Biology