Author

A. S. Flies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Zoology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:Drosophila· 2 Organism:mouse· 2 Organism:non-human primate· 2 Assay:proteomics· 2

Frequent Co-Authors

A. B. Lyons· 5 shared J. M. Darby· 5 shared G. M. Woods· 4 shared A. L. Patchett· 3 shared C. E. B. Ong· 3 shared A. T. Gilbert· 2 shared G.-S. Liu· 2 shared N. M. Fountain-Jones· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersImmunology

A. B. Lyons

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Conversion of mouse-derived hybridomas to Tasmanian devil recombinant IgG antibodies

B. Slyp, J. M. Darby, A. S. Flies

This paper converts mouse-derived hybridoma antibodies into Tasmanian devil recombinant IgG antibodies for use in functional assays and immunotherapy.

bioRxiv · Oct 20, 2023 · PreprintImmunology

Automated analysis of PD1 and PDL1 in lymph nodes and the microenvironment of transmissible tumors in Tasmanian devils

G. G. Russell, C. Palmieri, J. Darby, G. P. Morris, N. M. Fountain-Jones, R. Pye, A. S. Flies

This study uses QuPath to analyze PD1 and PDL1 expression in Tasmanian devil lymph nodes, finding higher PD1 expression in germinal centers and increased PD1-positive cells in DFT2 metastases.

bioRxiv · Oct 31, 2022Immunology

A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I

A. N. Kayigwe, J. M. Darby, A. B. Lyons, A. L. Patchett, L. Lisowski, G.-S. Liu, A. S. Flies

This study shows a human adenovirus encoding IFN-γ can upregulate MHC-I in Tasmanian devil tumor cells, suggesting its potential as a vaccine platform.

bioRxiv · May 29, 2022Immunology

Evaluation of oral baits and distribution methods for Tasmanian devils (Sarcophilus harrisii)

S. Dempsey, R. J. Pye, A. T. Gilbert, S. Benson-Amram, N. M. Fountain-Jones, J. M. Moffat, T. J. Smyser, A. S. Flies

This study evaluates oral baits as vaccine delivery vehicles for Tasmanian devils, finding that captive and wild devils consume placebo baits but face competition from non-target species, with automated dispensers improving uptake.

bioRxiv · Apr 13, 2022Zoology

Ethyl-Iophenoxic acid as a serum marker for oral baiting of carnivorous marsupials

R. Pye, D. S. Nichols, A. T. Gilbert, A. S. Flies

This study tests Et-IPA as a biomarker for oral bait consumption in Tasmanian devils, finding it remains detectable in serum for at least 56 days.

bioRxiv · Dec 14, 2021 · PreprintZoology

CIITA induces expression of MHC-I and MHC-II in transmissible cancers

C. E. B. Ong, Y. Cheng, H. Siddle, A. B. Lyons, G. M. Woods, A. S. Flies

This paper shows that CIITA upregulates MHC-I and MHC-II in transmissible cancers, with differential protein expression and functional implications for immune evasion.

bioRxiv · Jul 14, 2021 · PreprintImmunology

NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers

C. E. B. Ong, A. L. Patchett, J. M. Darby, J. Chen, G.-S. Liu, A. B. Lyons, G. M. Woods, A. S. Flies

This study shows NLRC5 upregulates MHC-I in transmissible cancers, making MHC-I a target for anti-tumor immunity and informing immunotherapy strategies.

bioRxiv · Sep 6, 2020Immunology

Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cells

C. Wong, J. M. Darby, P. R. Murphy, T. L. Pinfold, P. R. Lennard, G. M. Woods, A. B. Lyons, A. S. Flies

This study shows Tasmanian devil CTLA4 and CD28 can capture CD80 and CD86 from adjacent cells, similar to other species, suggesting potential for checkpoint immunotherapy in divergent species.

bioRxiv · Jun 11, 2020Immunology

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers

A. S. Flies, J. M. Darby, P. R. Lennard, P. R. Murphy, C. E. B. Ong, T. L. Pinfold, A. B. Lyons, G. M. Woods, A. L. Patchett

The paper develops a reagent method to study immune checkpoints in non-model species and identifies conserved immune evasion pathways in transmissible cancers.

bioRxiv · Jan 3, 2020Immunology