Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
B. F. Brian, A. S. Jolicoeur, C. R. Guerrero, M. G. Nunez, Z. E. Sychev, S. A. Hegre, P. Satrom, N. Habib, J. M. Drake, K. L. Schwertfeger, T. S. Freedman
The paper identifies how LynA is selectively degraded in macrophages via c-Cbl targeting tyrosine 32, while mast cells, with low c-Cbl, maintain high LynA levels, affecting signaling.
bioRxiv · Jul 2, 2019Biochemistry