J. M. Drake

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

The paper characterizes the proteome and phosphoproteome of prostate cancer patient-derived xenografts to identify differences between neuroendocrine-like and adenocarcinoma subtypes.

Adipose triglyceride lipase is regulated by CAMKK2-AMPK signaling and drives advanced prostate cancer

This study identifies ATGL as a CAMKK2-AMPK target that promotes CRPC progression by enhancing lipase activity and metabolic plasticity, suggesting it as a therapeutic target.

An integrative approach to mosquito dynamics reveals differences in people's everyday experiences of mosquitoes

The paper uses an integrative approach to study mosquito dynamics in urban areas, finding differences in people's experiences with mosquitoes despite no difference in abundance.

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

This study identifies CREB5 as a key driver of resistance to androgen receptor targeting therapies by reprogramming nuclear interactions and activating TGFβ and Wnt signaling pathways.

Predictors of zoonotic potential in helminths

The paper identifies predictors of zoonotic potential in helminths using a global dataset, finding that transmission and geographic traits are more important than morphology or epidemiology.

Massively parallel, computationally-guided design of a pro-enzyme

This paper designs pro-enzymes using computational methods and validates their activity regulation through protease cleavage.

Spatial spread of white-nose syndrome in North America, 2006-2018

The paper analyzes the spatial spread of white-nose syndrome in North America from 2006-2018, finding changing factors influencing its spread over time.

Identification of clinical combination therapies to induce durable responses in kidney cancers

This study identifies a synergistic combination of cabozantinib and dasatinib that reduces viability and induces tumor regression in NCCRCC, with mechanisms involving MAPK-ERK pathway suppression.

Assessing temperature-dependent competition between two invasive mosquito species

This study assesses temperature-dependent competition between Aedes aegypti and Anopheles stephensi, finding Ae. aegypti dominates due to higher larval survival and growth rates across temperatures.

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

Protective Population Behavior Change in Outbreaks of Emerging Infectious Disease

The paper analyzes changes in removal rates and hospitalization times during outbreaks of EVD, SARS, and MERS to assess population behavior changes.

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

The paper identifies how LynA is selectively degraded in macrophages via c-Cbl targeting tyrosine 32, while mast cells, with low c-Cbl, maintain high LynA levels, affecting signaling.

Targeting RET Kinase in Neuroendocrine Prostate Cancer

The paper identifies RET kinase as a targetable driver in neuroendocrine prostate cancer (NEPC) through phosphoproteomics and pharmacological inhibition studies, showing reduced tumor growth in models.

Microclimate and larval habitat density predict adult Aedes albopictus abundance in urban areas

Do Synthesis Centers Synthesize? A Semantic Analysis of Diversity and Performance

This study analyzes whether synthesis center publications are more diverse than others, finding greater variety and balance but less disparity, even after accounting for collaboration size.